The Psychiatric And Developmental Imaging Laboratory (PADIL) is focused on using brain imaging technology to better understand brain development and mental illness. At present, psychiatry remains one of the few medical disciplines where diagnosis, determination of prognosis, and clinical decision-making occurs without the benefit of imaging or other laboratory data. Our over-arching goal is bridge this gap by helping uncover the biological origins of mental illness, which is a prerequisite for novel targeted therapies which may improve outcomes. Many major mental illnesses are increasingly conceptualized as disorders of brain development. Accordingly, most of our work focuses on the critical period of adolescence and young adulthood, which is when many illness first begin. Our research uses multi-modal brain imaging to gain complementary views on brain structure and function. Such high-dimensional data is integrated with detailed assessments of symptoms and cognition using advanced analytics, in order to uncover novel mechanisms of psychiatric illness. Led by Ted Satterthwaite, the lab is located within the Neuropsychiatry section (led by Raquel Gur), and closely integrated with the Brain Behavior Laboratory (directed by Ruben Gur).
We are grateful for the current and past support of funding agencies including NIMH, the Brain Behavior Research Foundation, ITMAT, and CBICA. The lab is currently funded through a NIMH BRAINS award (R01 MH107703), a collaborative NIMH R01 with Taki Shinohara ( R01MH112847), and a collaborative NIMH R21 with Dani Bassett (R21 MH106799). Further support is provided by ongoing NIH-funded collaborations with Dan Wolf ( R01MH101111), C. Neil Epperson (R01DA037289), Ruben Gur (R01MH107235), Christos Davatzikos & Yong Fan (R01EB022573), and Yvette Sheline (U01MH109991.