Dr. Antonia Kaczkurkin (a post-doc in the lab) has just had an article entitled "Elevated Amygdala Perfusion Mediates Developmental Sex Differences in Trait Anxiety" accepted at Biological Psychiatry. Using data from the PNC, this paper demonstrates that elevated perfusion in limbic regions such as the amygdala and anterior insula which are critical for emotion processing is associated with symptoms of anxiety in adolescents and young adults (see Figure). Notably, these same regions show marked developmental sex differences, with females having higher pefusion in late adolescence than males. Critically, elevated levels of anxiety symptoms in post-pubertal females are mediated by elevated perfusion in the amygdala. This work provides new insights regarding biological mechanisms of differential vulnerability to anxiety and mood symptoms, which are more common in females than males. Well done, Antonia!!