The Psychiatric and Developmental Imaging Laboratory

Richards Research Labs, 5th Floor

3700 Hamilton Walk

Philadelphia, PA 19104

Email: sattertt@pennmedicine.upenn.edu

Selected Publications

Rastko Ciric

We define a structured protocol for the evaluation and mitigation of motion artifact in functional connectivity MRI.

Nature Protocols

Protocol for mitigating motion artifact

Rula Nassar & Antonia Kaczkurkin

Prematurity is associated with the deficit in executive function and abnormalities in structural covariance networks.

Cerebral Cortex

Prematurity and Structural Brain Development

Marieta Pehlivanova

In collaboration with Joe Kable, we demonstrate that impulsive choice during adolescence is associated with reduced cortical thickness in regions critical for reward valuation.

Journal of Neuroscience

Cortical thickness and adolescent impulsivity

Antonia Kaczkurkin

Higher levels of overall psychopathology across disorders are associated with differences in cerebral blood flow in key brain regions such as the anterior cingulate cortex.

Molecular Psychiatry

Overall psychopathology and cerebral blood flow

Graham Baum

Structural brain networks grow more segregated during adolescent development, and support executive functioning.

larry david.jpg

Current Biology

Development of Structural Brain Networks

Antonia Kaczkurkin

We demonstrate that normative developmental sex differences in perfusion of brain regions involved in emotion and social cognition -- such as the amygdala-- mediate established sex differences in mood and anxiety symptoms in youth.

Biological Psychiatry

Amygala perfusion and anxiety

Sheila Shanmugan

We review recent work investigating the neural basis for executive development during childhood and adolescence.

larry david.jpg

Curr Op in Behav Science

Review article: Executive function and development

Ted Satterthwaite

Similar reward system deficits are dimensionally present in both unipolar and bipolar depression.

Neuropsychopharmacology

Common reward deficits in unipolar and bipolar depression

Ted Satterthwaite

This provides an overview of the imaging procedures of the PNC, a large-scale NIMH-funded study (PI: Raquel E. Gur).

NeuroImage

Neuroimaging of the Philadelphia Neurodevelopmental Cohort

Ted Satterthwaite

We provide one of the first descriptions of motion artifact's impact on functional connectivity.

NeuroImage

Motion and functional connectivity

Cedric Xia

Machine-learning links dimensions of psychopathology to abnormalities of functional brain networks.

larry david.jpg

Nature Communications

Dimensions of Psychopathology and Functional Brain Network

Adon Rosen

We assessed quantitative metrics of structural image quality, and described how image quality may impact inference about brain development.

Neuoimage

Quantitative assessment of structural image quality

Evelyn Tang

In collaborative work with Danielle Bassett, we show that brain networks become more controllable with development in adolescence.

Nature Communications

Network control in brain development

Anup Sharma

We delineate common functional connectivity abnormalities in the brain's reward system across mood and psychotic disorders.

American Journal of Psychiatry

Reward dysconnectivity in psychiatry

Shi Gu

In collaborative work with Danielle Bassett, we uncover novel developmental network features in high-resolution network hypergraphs.

Human Brain Mapping

Hypergraphs in developing networks

Simon Vandekar

Here we introduce a new measure --cortical coupling-- that describes the local association between brain measures.

NeuroImage

Cortical coupling

Sheila Shanmugan

We investigated executive system deficits in association with dimensions of psychiatric symptoms in youth using a working memory paradigm.

larry david.jpg

American Journal of Psychiatry

Transdiagnostic Executive Dysfunction in Youth

Simon Vandekar

Here we show that cortical thinning in adolescence is partially governed by sulcal topology.

Journal of Neuroscience

Cortical topology and development

Ted Satterthwaite

Using fMRI and machine learning tools, we demonstrate that executive system activation is more strongly linked to individual differences in performance ability than chronological age.

Journal of Neuroscience

Functional Maturation of the Executive System

Graham Baum

The impact of in-scanner head motion on structural connectivity derived from diffusion MRI.

larry david.jpg

NeuroImage

Motion and Diffusion-Based Structural Networks

Cedric Xia

We aim to offer an accessible introduction to this emerging field and motivate further work that uses NN to better understand the normative development of brain networks and alterations in that development that accompany or foreshadow psychiatric disease.

larry david.jpg

Biological Psychiatry: CNNI

Review article: Network neuroscience and neuropsychiatric disorders

Ted Satterthwaite

This review article provides an overview of the way in-scanner motion impacts functional connectivity data, as well as common approaches for mitigating this artifact.

Human Brain Mapping

Review article: Motion and functional connectivity

Rastko Ciric

We benchmark 14 of the most commonly used preprocessing pipelines for functional connectivity. This paper was one of the top 3 cited papers in 2017 published in NeuroImage.

NeuroImage

Benchmarking functional connectivity pipelines

Aris Sotiras

In collaborative work with Christos Davatzikos, we define novel structural covariance networks, and show that their development during adolescence is associated with evolutionary expansion.

PNAS

Developmental cortical networks and evolutionary expansion

Ted Satterthwaite

We document structural brain abnormalities in youth with psychosis-spectrum symptoms, including medial temporal lobe regions such as the hippocampus.

JAMA Psychiatry

Structural brain abnormalities in psychosis spectrum youth

Shi Gu

In collaborative work with Danielle Bassett, we track how the roles of functional sub-networks evolve in adolescence.

PNAS

Functional network development in adolescence

Ted Satterthwaite

We delineate fundamental normative sex differences in CBF evolution during adolescence.

PNAS

Sex differences in cerebral blood flow in adolescence

Ted Satterthwaite

We introduce a top-performing strategy for reducing motion artifact in functional connectivity data.

NeuroImage

Preprocessing for motion artifact