The Psychiatric and Developmental Imaging Laboratory

Richards Research Labs, 5th Floor

3700 Hamilton Walk

Philadelphia, PA 19104

Email: sattertt@pennmedicine.upenn.edu

Selected Publications

Graham Baum

Coupling between structural and functional brain networks evolves in a hierarchy-dependent manner in youth

PNAS

Development of Structure Function Coupling

Antonia Kaczkurkin

We used a semi-supervised machine learning tool to parse heterogeneity in mood and anxiety disorders in youth

Biological Psychiatry

Neurostructural Heterogenity in Mood and Anxiety Disorders

Adam Pines

We find key advantages of multi-shell diffusion metrics, including increased neurodevelopmental coupling and decreased spurious relationships with imaging data quality.

bioarxiv

Advantages of Multi-shell Diffusion for Studying Neurodevelopment

Graham Baum

The impact of in-scanner head motion on structural connectivity derived from diffusion MRI.

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NeuroImage

Motion and Diffusion-Based Structural Networks

Cedric Xia

We aim to offer an accessible introduction to this emerging field and motivate further work that uses NN to better understand the normative development of brain networks and alterations in that development that accompany or foreshadow psychiatric disease.

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Biological Psychiatry: CNNI

Review: Network neuroscience and neuropsychiatric disorders

Evelyn Tang

In collaborative work with Danielle Bassett, we show that brain networks become more controllable with development in adolescence.

Nature Communications

Network control in brain development

Rastko Ciric

We benchmark 14 of the most commonly used preprocessing pipelines for functional connectivity. This paper was one of the top 3 cited papers in 2017 published in NeuroImage.

NeuroImage

Benchmarking functional connectivity pipelines

Aris Sotiras

In collaborative work with Christos Davatzikos, we define novel structural covariance networks, and show that their development during adolescence is associated with evolutionary expansion.

PNAS

Developmental cortical networks and evolutionary expansion

Ted Satterthwaite

We document structural brain abnormalities in youth with psychosis-spectrum symptoms, including medial temporal lobe regions such as the hippocampus.

JAMA Psychiatry

Structural brain abnormalities in psychosis spectrum youth

Shi Gu

In collaborative work with Danielle Bassett, we track how the roles of functional sub-networks evolve in adolescence.

PNAS

Functional network development in adolescence

Antonia Kaczkurkin

This review provides an overview of methods for defining common and dissociable aspects of psychopathology

Biological Psychiatry

Review: Parsing Heterogeneity in Psychopathology

Robert J. Jirsaraie

Irritability is associated with accelerated cortical thinning in youth

Neuropsychopharmacology

Irritability and Longitudinal Brain Development

Rastko Ciric

We define a structured protocol for the evaluation and mitigation of motion artifact in functional connectivity MRI.

Nature Protocols

Protocol for mitigating motion artifact

Rula Nassar & Antonia Kaczkurkin

Prematurity is associated with the deficit in executive function and abnormalities in structural covariance networks.

Cerebral Cortex

Prematurity and Structural Brain Development

Marieta Pehlivanova

In collaboration with Joe Kable, we demonstrate that impulsive choice during adolescence is associated with reduced cortical thickness in regions critical for reward valuation.

Journal of Neuroscience

Cortical thickness and adolescent impulsivity

Antonia Kaczkurkin

Higher levels of overall psychopathology across disorders are associated with differences in cerebral blood flow in key brain regions such as the anterior cingulate cortex.

Molecular Psychiatry

Overall psychopathology and cerebral blood flow

Graham Baum

Structural brain networks grow more segregated during adolescent development, and support executive functioning.

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Current Biology

Development of Structural Brain Networks

Antonia Kaczkurkin

We demonstrate that normative developmental sex differences in perfusion of brain regions involved in emotion and social cognition -- such as the amygdala-- mediate established sex differences in mood and anxiety symptoms in youth.

Biological Psychiatry

Amygala perfusion and anxiety

Sheila Shanmugan

We review recent work investigating the neural basis for executive development during childhood and adolescence.

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Curr Op in Behav Science

Review: Executive function and development

Ted Satterthwaite

Similar reward system deficits are dimensionally present in both unipolar and bipolar depression.

Neuropsychopharmacology

Common reward deficits in unipolar and bipolar depression

Antonia Kaczkurkin

Dissociable impact of dimensions of psychopathology on brain structure

American Journal of Psychiatry

Dimensions of Psychopathology and Brain Structure

Shi Gu

We a recently-developed stochastic block model that simultaneously uncovers modular and core–periphery structure

Cerebral Cortex

Unifying Modular and Core-Periphery Networks

Cedric Xia

Machine-learning links dimensions of psychopathology to abnormalities of functional brain networks.

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Nature Communications

Dimensions of Psychopathology and Functional Brain Network

Adon Rosen

We assessed quantitative metrics of structural image quality, and described how image quality may impact inference about brain development.

Neuoimage

Quantitative assessment of structural image quality

Ted Satterthwaite

This review article provides an overview of the way in-scanner motion impacts functional connectivity data, as well as common approaches for mitigating this artifact.

Human Brain Mapping

Review: Motion and functional connectivity

Anup Sharma

We delineate common functional connectivity abnormalities in the brain's reward system across mood and psychotic disorders.

American Journal of Psychiatry

Reward dysconnectivity in psychiatry

Shi Gu

In collaborative work with Danielle Bassett, we uncover novel developmental network features in high-resolution network hypergraphs.

Human Brain Mapping

Hypergraphs in developing networks

Simon Vandekar

Here we introduce a new measure --cortical coupling-- that describes the local association between brain measures.

NeuroImage

Cortical coupling

Sheila Shanmugan

We investigated executive system deficits in association with dimensions of psychiatric symptoms in youth using a working memory paradigm.

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American Journal of Psychiatry

Transdiagnostic Executive Dysfunction in Youth

Simon Vandekar

Here we show that cortical thinning in adolescence is partially governed by sulcal topology.

Journal of Neuroscience

Cortical topology and development